In vitro cultured human term cytotrophoblast: a model for normal primary epithelial cells demonstrating a spontaneous differentiation programme that requires EGF for extensive development of syncytium.

@article{Morrish1997InVC,
  title={In vitro cultured human term cytotrophoblast: a model for normal primary epithelial cells demonstrating a spontaneous differentiation programme that requires EGF for extensive development of syncytium.},
  author={Donald W. Morrish and Jamal Dakour and H Li and Junsong Xiao and Ryan F Miller and Richard K. Sherburne and Robert C. Berdan and Larry J. Guilbert},
  journal={Placenta},
  year={1997},
  volume={18 7},
  pages={
          577-85
        }
}
Normal human term cytotrophoblast cells prepared by trypsin-DNAse I digestion with and without secondary immunological purification with CD9 antibodies were investigated for the expression of morphological and genetic markers of proliferation and differentiation. After 24 h of culture, the cell preparations demonstrated spontaneous formation of microvilli and formation of small syncytial units as assessed by desmoplakin staining and FITC-dextran microinjection. EGF was required for mature… CONTINUE READING

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