In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression.

@article{Levesque1996InVC,
  title={In vitro culture of human peripheral blood monocytes induces hyaluronan binding and up-regulates monocyte variant CD44 isoform expression.},
  author={Marc C. Levesque and Barton F Haynes},
  journal={Journal of immunology},
  year={1996},
  volume={156 4},
  pages={1557-65}
}
CD44 is a cell surface proteoglycan homologous to cartilage link protein that serves as a receptor for hyaluronan (HA). CD44 isoforms include an unspliced 80- to 90-kDa standard form (CD44S) and isoforms derived from alternative splicing of nine CD44 variant exons (CD44V). Ligation of CD44 isoforms on monocytes induces the production of IL-1 and TNF-alpha. In addition, CD44 mAbs and HA inhibit HIV infection of monocytes by monocytotropic HIV, but do not inhibit T cell tropic HIV infectivity of… CONTINUE READING