In vitro culture of colony forming unit-megakaryocyte (CFU-MK) in fetal alloimmune thrombocytopenia.

@article{Warwick1994InVC,
  title={In vitro culture of colony forming unit-megakaryocyte (CFU-MK) in fetal alloimmune thrombocytopenia.},
  author={Ruth M. Warwick and Janet Vaughan and Neil A Murray and Anatole Lubenko and Irene A. G. Roberts},
  journal={British journal of haematology},
  year={1994},
  volume={88 4},
  pages={874-7}
}
Perinatal alloimmune thrombocytopenia (PAITP) causes intracranial haemorrhage in the fetus and neonate. However, the severity of the thrombocytopenia correlates poorly with maternal anti-platelet antibody titres. To test the hypothesis that reduced platelet production contributes to fetal thrombocytopenia in PAITP, maternal sera from three HPA-1a-negative mothers whose pregnancies were complicated by anti-HPA-1a (two severe cases, one mild case) were added to colony forming unit-megakaryocyte… CONTINUE READING