In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.

@article{Cordillot2013InVC,
  title={In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.},
  author={Mathilde Cordillot and Vincent Dub{\'e}e and S{\'e}bastien Triboulet and Lionel Dubost and Angela Marie and Jean-Emmanuel Hugonnet and Michel Arthur and J R Mainardi},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 12},
  pages={
          5940-5
        }
}
The Mycobacterium tuberculosis peptidoglycan is cross-linked mainly by l,d-transpeptidases (LDTs), which are efficiently inactivated by a single β-lactam class, the carbapenems. Development of carbapenems for tuberculosis treatment has recently raised considerable interest since these drugs, in association with the β-lactamase inhibitor clavulanic acid, are uniformly active against extensively drug-resistant M. tuberculosis and kill both exponentially growing and dormant forms of the bacilli… CONTINUE READING
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