In vitro correlates of transformation in C3H/10T1/2 clone 8 mouse cells.

@article{Jones1976InVC,
  title={In vitro correlates of transformation in C3H/10T1/2 clone 8 mouse cells.},
  author={Peter A. Jones and Walter E. Laug and Agnes Gardner and C. A. Nye and Louis M. Fink and William F. Benedict},
  journal={Cancer research},
  year={1976},
  volume={36 8},
  pages={2863-7}
}
Various potential in vitro correlates of malignancy were studied in four chemically transformed C3H/10T1/2 Clone 8 mouse cell lines and were compared with controls cells. The degree of tumorigenicity was best predicted by the relative plating efficiencies of the morphologically transformed cells in soft agar. All transformed cells also showed an increase in extracellular fibrinolytic activity which may be an additional marker for transformation. Intracellular fibrinolytic activity and loss of… CONTINUE READING

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