In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution.

@article{Arendt1983InVC,
  title={In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution.},
  author={Rainer M. Arendt and David J Greenblatt and R H deJong and J D Bonin and Darrell R. Abernethy and Bruce L. Ehrenberg and Harlan Giles and Edward M. Sellers and Richard I. Shader},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1983},
  volume={227 1},
  pages={98-106}
}
Factors influencing the rate and extent of benzodiazepine uptake into cerebrospinal fluid (CSF), peripheral tissue distribution and electroencephalographic (EEG) effects were evaluated in a model utilizing anesthetized male cats. A single (0.25-10 mg/kg) dose of the following eight benzodiazepines was administered i.v.: diazepam, desmethyldiazepam, midazolam, lorazepam, alprazolam, triazolam, flunitrazepam and clobazam. Multiple samples were simultaneously drawn from arterial blood and… CONTINUE READING