In vitro corneal permeation of diclofenac from oil drops.

@article{Ahuja2007InVC,
  title={In vitro corneal permeation of diclofenac from oil drops.},
  author={M. Ahuja and Surendra K Sharma and D. K. Majumdar},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  year={2007},
  volume={127 10},
  pages={
          1739-45
        }
}
In vitro transcorneal permeation of diclofenac from oil drops was studied using freshly excised goat cornea. The maximum apparent corneal permeability coefficient (Papp) was obtained with 0.2% (w/v) diclofenac drops in sesame oil followed by safflower oil, while formulation in castor oil provided minimal Papp. The addition of benzyl alcohol, a preservative, in oil drops, increased the Papp value of diclofenac. Partition experiments indicated increased partitioning of diclofenac in the aqueous… Expand
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