In vitro cleavage of hepatitis B virus C mRNA by 10-23 DNA enzyme.

BACKGROUND 10-23 DNA enzyme is one kind of deoxyribozymes for RNA cleavage. The inhibition effects of 10-23 DNA enzyme on the expression of the HBV C gene in HepG2.2.15 cells were demonstrated previously. The aim of this study was to further explore the cleavage activities of 10-23 DNA enzyme targeting at HBV C gene mRNA in vitro. METHODS 10-23 DNA enzyme… (More)