In vitro cleavage and joining at the viral origin of replication by the replication initiator protein of tomato yellow leaf curl virus.

@article{Laufs1995InVC,
  title={In vitro cleavage and joining at the viral origin of replication by the replication initiator protein of tomato yellow leaf curl virus.},
  author={J. Laufs and W. Traut and F. Heyraud and V. Matzeit and S. G. Rogers and J. Schell and B. Gronenborn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92},
  pages={3879 - 3883}
}
  • J. Laufs, W. Traut, +4 authors B. Gronenborn
  • Published 1995
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Replication of the single-stranded DNA genome of geminiviruses occurs via a double-stranded intermediate that is subsequently used as a template for rolling-circle replication of the viral strand. Only one of the proteins encoded by the virus, here referred to as replication initiator protein (Rep protein), is indispensable for replication. We show that the Rep protein of tomato yellow leaf curl virus initiates viral-strand DNA synthesis by introducing a nick in the plus strand within the… Expand
A DNA structure is required for geminivirus replication origin function.
Functional Analysis of cis- and trans-Acting Replication Factors of Porcine Circovirus Type 1
Functional Domains of a Geminivirus Replication Protein*
The structure of a replication initiator unites diverse aspects of nucleic acid metabolism
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References

DNA replication: the rolling circle model.