In vitro chondrogenesis and in vivo repair of osteochondral defect with human induced pluripotent stem cells.

@article{Ko2014InVC,
  title={In vitro chondrogenesis and in vivo repair of osteochondral defect with human induced pluripotent stem cells.},
  author={Ji-Yun Ko and Kyung-Il Kim and Siyeon Park and Gun-Il Im},
  journal={Biomaterials},
  year={2014},
  volume={35 11},
  pages={3571-81}
}
The purpose of this study was to investigate the chondrogenic features of human induced pluripotent stem cells (hiPSCs) and examine the differences in the chondrogenesis between hiPSCs and human bone marrow-derived MSCs (hBMMSCs). Embryoid bodies (EBs) were formed from undifferentiated hiPSCs. After EBs were dissociated into single cells, chondrogenic culture was performed in pellets and alginate hydrogel. Chondro-induced hiPSCs were implanted in osteochondral defects created on the patellar… CONTINUE READING
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