In vitro characterization of self-assembled anterior cruciate ligament cell spheroids for ligament tissue engineering

@article{Hoyer2014InVC,
  title={In vitro characterization of self-assembled anterior cruciate ligament cell spheroids for ligament tissue engineering},
  author={Mariann Hoyer and Carola Meier and Annette Breier and Jason L Hahner and Gert Heinrich and Nikita Drechsel and Michael T. Meyer and Claudia Rentsch and Laura M. Garbe and Wolfgang Ertel and Anke Lohan and Gundula G. Schulze-Tanzil},
  journal={Histochemistry and Cell Biology},
  year={2014},
  volume={143},
  pages={289-300}
}
Tissue engineering of an anterior cruciate ligament (ACL) implant with functional enthesis requires site-directed seeding of different cell types on the same scaffold. Therefore, we studied the suitability of self-assembled three-dimensional spheroids generated by lapine ACL ligament fibroblasts for directed scaffold colonization. The spheroids were characterized in vitro during 14 days in static and 7 days in dynamic culture. Size maintenance of self-assembled spheroids, the vitality, the… CONTINUE READING
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