In vitro characterization of estrogen induced syrian hamster renal tumors: Comparison with an immortalized cell line derived from diethylstilbestrol-treated adult hamster kidney

@article{Gonzalez1993InVC,
  title={In vitro characterization of estrogen induced syrian hamster renal tumors: Comparison with an immortalized cell line derived from diethylstilbestrol-treated adult hamster kidney},
  author={Alfonso Gonzalez and Terry D. Oberley and Janice L. Schultz and Jennifer Ostrom and Jonathan S. Li},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={1993},
  volume={29},
  pages={562-573}
}
Primary diethylstilbestrol-induced kidney tumors from Syrian hamsters were grown in vitro and maintained in culture for 6 mo. Combined immunohistochemical studies using antibodies to intermediate filaments and ultrastructural studies of tumor cells in culture exhibited characteristics similar to tumor cells in vivo. Furthermore, the cells manifested transformed properties in culture; they grew both as multilayered colonies attached to the tissue culture substrate and as floating multicellular… CONTINUE READING