In vitro characterization of cytochrome P450 catalysed metabolism of the antiemetic tropisetron.

@article{Firkusny1995InVC,
  title={In vitro characterization of cytochrome P450 catalysed metabolism of the antiemetic tropisetron.},
  author={L. Firkusny and H. Kroemer and M. Eichelbaum},
  journal={Biochemical pharmacology},
  year={1995},
  volume={49 12},
  pages={
          1777-84
        }
}
  • L. Firkusny, H. Kroemer, M. Eichelbaum
  • Published 1995
  • Chemistry, Medicine
  • Biochemical pharmacology
  • The new 5-hydroxytryptamine type 3 (5HT3) receptor antagonist tropisetron is used in the treatment of chemotherapy-related nausea. The drug is extensively metabolized in man, with the enzymes involved in tropisetron biotransformation being unknown. Identification of these enzymes would make it possible to predict both interindividual variability in plasma concentrations and metabolic interaction potential. The present in vitro study was therefore aimed at identifying and characterizing the… CONTINUE READING
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