In vitro characterization of SLV308 (7‐[4‐methyl‐1‐piperazinyl]‐2(3H)‐benzoxazolone, monohydrochloride): A novel partial dopamine D2 and D3 receptor agonist and serotonin 5‐HT1A receptor agonist

@article{Glennon2006InVC,
  title={In vitro characterization of SLV308 (7‐[4‐methyl‐1‐piperazinyl]‐2(3H)‐benzoxazolone, monohydrochloride): A novel partial dopamine D2 and D3 receptor agonist and serotonin 5‐HT1A receptor agonist},
  author={Jeffrey C. Glennon and Guus van Scharrenburg and Eric Ronken and Mayke B. Hesselink and Jan Hendrik Reinders and Martina A W van der Neut and Stephen K. Long and Rolf W. Feenstra and Andrew C McCreary},
  journal={Synapse},
  year={2006},
  volume={60}
}
Present Parkinson's disease treatment strategies are far from ideal for a variety of reasons; it has therefore been suggested that partial dopamine receptor agonism might be a potential therapeutic approach with potentially fewer side effects. In the present study, we describe the in vitro characterization of the nonergot ligand SLV308 (7‐[4‐methyl‐1‐piperazinyl]‐2(3H)‐benzoxazolonemonohydrochloride). SLV308 binds to dopamine D2, D3, and D4 receptors and 5‐HT1A receptors and is a partial… 
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