In vitro characterisation of the interaction between newly synthesised proteins and a pancreatic isoform of protein disulphide isomerase.

@article{Elliott1998InVC,
  title={In vitro characterisation of the interaction between newly synthesised proteins and a pancreatic isoform of protein disulphide isomerase.},
  author={Julian G. Elliott and Jason D. Oliver and J{\"o}rg Volkmer and Richard Zimmermann and Stephen High},
  journal={European journal of biochemistry},
  year={1998},
  volume={252 3},
  pages={372-7}
}
The lumen of the endoplasmic reticulum (ER) contains an array of molecular chaperones and folding factors that modulate the folding and assembly of newly synthesised proteins entering the secretory pathway. One of these components, protein disulphide isomerase (PDI), facilitates the formation of the correct disulphide bonds within newly synthesised polypeptides, and is the archetype for a family of sequence related PDI-like proteins. We have investigated the interaction between a recently… CONTINUE READING