• Corpus ID: 202041269

In vitro characterisation and modulation of evolving epileptiform activity

@inproceedings{Codadu2018InVC,
  title={In vitro characterisation and modulation of evolving epileptiform activity},
  author={Neela K. Codadu},
  year={2018}
}
Understanding the role of different neuronal populations in the evolution of epileptic activity remains a major goal for epilepsy research. Physiological neuronal networks may become hyperexcitable if they tip over some apparent threshold level of excitation, or below some threshold level of inhibition, although this process, termed ictogenesis is not understood. This hyperexcitable state of the network underlies the pathological condition of epilepsy. Clinical evidence suggests strongly that… 

References

SHOWING 1-10 OF 164 REFERENCES
Strategies for the Development of Drugs for Pharmacoresistant Epilepsies
TLDR
Most strategies for development of antiepileptic drugs (AEDs) center around seizure models that are known to respond to presently marketed AEDs, butEpilepsy induced alterations in the interaction between the EC and the hippocampus may lead to alterations that facilitate precipitation of seizures.
The use of organotypic slice cultures for the study of epileptogenesis
  • R. Koyama
  • Biology
    Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2013
TLDR
The dentate granule cells exhibit aberrant migration in the dentate hilus via enhanced excitatory GABAA receptor (GABAA‐R) signaling, which results in granule cell ectopia that persists into adulthood and is associated with spontaneous limbic seizures in adulthood.
Mechanisms underlying the neuropathological consequences of epileptic activity in the rat hippocampus in vitro
TLDR
It is concluded that NMDA receptor activation is not solely responsible for the neuronal pathology resulting as a consequence of epileptiform discharge, and coapplication of antagonists of both non‐NMDA and NMDA receptors strongly reduced the degeneration induced by the convulsants.
An astrocytic basis of epilepsy
TLDR
It is reported that paroxysmal depolarization shifts can be initiated by release of glutamate from extrasynaptic sources or by photolysis of caged Ca2+ in astrocytes, and this finding identifies astroCytes as a proximal target for the treatment of epileptic disorders.
Seizure-like events in brain slices: suppression by interictal activity
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro
Modulation of Immunity and the Inflammatory Response: A New Target for Treating Drug-resistant Epilepsy
TLDR
The above emerging evidence indicates that modulation of immunity and inflammatory processes could serve as novel specific targets to achieve potential anticonvulsant effects for the patients with epilepsy, especially DRE.
KCC2 activity is critical in limiting the onset and severity of status epilepticus
TLDR
It is shown that SE leads to rapid dephosphorylation of residue serine 940, and it is demonstrated that deficits in S940 phosphorylation directly contribute to the onset and severity of SE.
Epilepsy after brain insult: Targeting epileptogenesis
TLDR
The latent period may offer a therapeutic window for the prevention of epileptogenesis and the development of unprovoked seizures and epilepsy in patients with common epileptogenic brain injuries.
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