In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia

@article{Klumper1995InVC,
  title={In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia},
  author={E. Klumper and Rob Pieters and Anjo J. P. Veerman and Dieuwke R. Huismans and Anne H. Loonen and Karel H{\"a}hlen and Gertjan J L Kaspers and Elisabeth R van Wering and Raimo Hartmann and Gunter Henze},
  journal={Blood},
  year={1995},
  volume={86 10},
  pages={3861-8}
}
Cellular drug resistance is thought to be an important cause of the poor prognosis for children with relapsed or refractory acute lymphoblastic leukemia (ALL), but it is unknown when, to which drugs, and to what extent resistance is present. We determined in vitro resistance to 13 drugs with the MTT assay. Compared with 141 children with initial ALL, cells from 137 children with relapsed ALL were significantly more resistant to glucocorticoids, L-asparaginase, anthracyclines, and thiopurines… CONTINUE READING

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