In vitro cellular aging is associated with enhanced proliferative capacity, G1 cell cycle modulation, and matrix metalloproteinase-9 regulation in mouse aortic smooth muscle cells.

@article{Moon2003InVC,
  title={In vitro cellular aging is associated with enhanced proliferative capacity, G1 cell cycle modulation, and matrix metalloproteinase-9 regulation in mouse aortic smooth muscle cells.},
  author={Sung-Kwon Moon and Byung-Yoon Cha and C -W Kim},
  journal={Archives of biochemistry and biophysics},
  year={2003},
  volume={418 1},
  pages={39-48}
}
Cellular and molecular events in young (passage 1-3) and aged (passage 25-30) primary mouse aortic smooth muscle cells (MASMC) were investigated. Immunoblot and immunofluorescence analyses indicated that smooth muscle alpha-actin (SM alpha-actin) levels were significantly reduced with increasing in vitro age. Aged MASMC showed an increased proliferative capacity in response to fetal bovine serum (FBS) in comparison with young MASMC. The cell cycle-associated proteins such as cyclin D1, cyclin E… CONTINUE READING
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