In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice

@article{Gordon1975InVC,
  title={In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice},
  author={R. Douglas Gordon and E Hatheway Simpson and Lawrence E Samelson},
  journal={The Journal of Experimental Medicine},
  year={1975},
  volume={142},
  pages={1108 - 1120}
}
C57BL/10 female mice were primed to the male specific antigen H-Y, either by grafting with syngeneic male tail skin or by i.p. injection of syngeneic male spleen cells. Primed female spleen cells, either unseparated or filtered through nylon wool to remove most of the B lymphocytes, were then cultured for 5 days in vitro with irradiated syngeneic male spleen cells and assayed against 51Cr-labeled target cells. Both unseparated and nylon wool filtered female cells displayed significant cytotoxic… CONTINUE READING

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