In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis.

@article{HrdiLanderer2008InVC,
  title={In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis.},
  author={Maria Christina H{\"a}rdi-Landerer and Maja M. Suter and Adrian Steiner and Max Michael Wittenbrink and Andrea Pickl and Bruno A Gander},
  journal={The Journal of antimicrobial chemotherapy},
  year={2008},
  volume={61 2},
  pages={332-40}
}
OBJECTIVES For the treatment of septic arthritis in large animals, the local application of antibiotics as a slow release system may be an appropriate means to reach high local bioactivity and low systemic side effects and drug residues. In this study, doxycycline microspheres were developed and tested in vitro for their drug-release properties, suitability for intra-articular application and antimicrobial activity. METHODS The development of a slow release system was achieved by… CONTINUE READING