In vitro cell aggregation and cell adhesion molecules in Crohn's disease.


BACKGROUND Lack of a suitable model has hindered efforts to understand inflammation and granuloma formation in Crohn's disease. METHODS Granulomalike aggregates of circulating mononuclear cells are produced in vitro by cultures of cells with polyacrylamide beads. To identify features of in vitro aggregates, which are similar to tissue granulomas of Crohn… (More)