In vitro blood-brain barrier models: current and perspective technologies.

  title={In vitro blood-brain barrier models: current and perspective technologies.},
  author={Pooja M Naik and Luca Cucullo},
  journal={Journal of pharmaceutical sciences},
  volume={101 4},
Even in the 21st century, studies aimed at characterizing the pathological paradigms associated with the development and progression of central nervous system diseases are primarily performed in laboratory animals. However, limited translational significance, high cost, and labor to develop the appropriate model (e.g., transgenic or inbred strains) have favored parallel in vitro approaches. In vitro models are of particular interest for cerebrovascular studies of the blood-brain barrier (BBB… CONTINUE READING


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