In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review.

@article{Pestieau2017InVB,
  title={In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review.},
  author={Aude Pestieau and Brigitte Evrard},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2017},
  volume={102},
  pages={203-219}
}
For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV… CONTINUE READING