In vitro biotransformation of tris(2-butoxyethyl) phosphate (TBOEP) in human liver and serum.

@article{Eede2015InVB,
  title={In vitro biotransformation of tris(2-butoxyethyl) phosphate (TBOEP) in human liver and serum.},
  author={Nele van den Eede and Claudio A Erratico and Vassiliki Exarchou and Walid Maho and Hugo M Neels and Adrian Covaci},
  journal={Toxicology and applied pharmacology},
  year={2015},
  volume={284 2},
  pages={246-53}
}
Tris(2-butoxyethyl) phosphate (TBOEP) is a plasticizer present in indoor dust, reaching levels of several micrograms per gram. Such levels could lead to significant daily exposure of adults and children. Currently, no toxicokinetic data are available to estimate TBOEP clearance in humans after uptake and therefore, one objective of this study was to investigate intrinsic clearance of TBOEP by human liver microsome (HLM) and serum enzymes. Another objective was to generate information to… CONTINUE READING
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