In vitro biosynthesis of ring-extended cyclosporins.

@article{Lawen1994InVB,
  title={In vitro biosynthesis of ring-extended cyclosporins.},
  author={Alfons Lawen and Rainer Traber and Rae L Reuille and Monique Ponelle},
  journal={The Biochemical journal},
  year={1994},
  volume={300 ( Pt 2)},
  pages={
          395-9
        }
}
Cyclosporin synthetase, a multifunctional polypeptide, catalyses the biosynthesis of the set of natural cyclosporins. We report that this enzyme is also capable of introducing a beta-alanine into position 7 or 8 of the ring instead of the alpha-alanines present at these positions in cyclosporin A. This leads to 34-membered rings in contrast to the 33-membered ring of the cyclo-undecapeptide cyclosporin A. Both [beta Ala7]CyA and [beta Ala8]CyA show immunosuppressive activity. The cyclosporin… CONTINUE READING

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