In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208).

@article{Khmelnitsky2013InVB,
  title={In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208).},
  author={Yuri L Khmelnitsky and Vadim V. Mozhaev and Ian C. Cotterill and Peter C. Michels and Sihem Boudjabi and Vladimir Khlebnikov and M Madhava Reddy and Gregory S. Wagner and Henrik C. Hansen},
  journal={European journal of medicinal chemistry},
  year={2013},
  volume={64},
  pages={121-8}
}
The structures of the two predominant metabolites (M4 and M5) of RVX-208, observed both in in vitro human and animal liver microsomal incubations, as well as in plasma from animal in vivo studies, were determined. A panel of biocatalytic systems was tested to identify biocatalysts suitable for milligram scale production of metabolite M4 from RVX-208. Rabbit… CONTINUE READING