In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.

@article{Peters1988InVB,
  title={In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.},
  author={Godefridus J. Peters and Jaap van Dijk and Emile J Laurensse and Cornelis J. van Groeningen and Jan Lankelma and Albert Leyva and Jorge C. Nadal and Herbert M. Pinedo},
  journal={British Journal of Cancer},
  year={1988},
  volume={57},
  pages={259 - 265}
}
The effect of delayed uridine administration on the in vitro growth inhibitory effects of 5-fluorouracil (5FU) and on the in vivo antitumour activity and toxicity was studied. In vitro growth inhibition of the human intestinal cell lines WiDr and Intestine 407 by 3 microM 5FU could be reversed by 1.0 mM uridine; the effect was more pronounced with WiDr cells. At 0.1 mM uridine an intermediate effect was observed. Inhibition of colony formation in both cell lines could also be reversed by… CONTINUE READING
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