In-vitro binding of propiverine hydrochloride and some of its metabolites to serum albumin in man.

@article{Meisel1997InvitroBO,
  title={In-vitro binding of propiverine hydrochloride and some of its metabolites to serum albumin in man.},
  author={Peter Meisel and Soenke Langner and Werner Siegmund},
  journal={The Journal of pharmacy and pharmacology},
  year={1997},
  volume={49 3},
  pages={270-2}
}
The distribution and pharmacological action of propiverine, a bladder spasmolytic agent, are affected by the extent of plasma-protein binding. Because attempts to assess the albumin-binding of propiverine have produced conflicting results, the binding parameters of the drug and some of its metabolites to serum albumin in man have been re-evaluated. In man propiverine is bound to serum albumin at a single site with high affinity (KA1 = 1.45 x 10(4) L mol-1) and at least two sites with low… CONTINUE READING

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