In vitro binding of [(11)C]raclopride with ultrahigh specific activity in rat brain determined by homogenate assay and autoradiography.

@article{Noguchi2008InVB,
  title={In vitro binding of [(11)C]raclopride with ultrahigh specific activity in rat brain determined by homogenate assay and autoradiography.},
  author={Junko Noguchi and Ming-Rong Zhang and Kazuhiko Yanamoto and Ryuji Nakao and Kazutoshi Suzuki},
  journal={Nuclear medicine and biology},
  year={2008},
  volume={35 1},
  pages={
          19-27
        }
}
OBJECTIVE The aim of this study was to characterize the in vitro binding of [(11)C]raclopride with ultrahigh specific activity (SA) in the striatum and cerebral cortex of rat brain. METHODS [(11)C]Raclopride, a dopamine D(2) receptor ligand, with an ultrahigh SA of 4880+/-2360 GBq/micromol (132+/-64 Ci/micromol, n=25) was synthesized. In vitro binding experiment was performed using brain homogenate assay and autoradiography (ARG). RESULTS In vitro homogenate assay demonstrated that high SA… CONTINUE READING

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