In vitro assessment of the allelic variants of cytochrome P450.

  title={In vitro assessment of the allelic variants of cytochrome P450.},
  author={Masahiro Hiratsuka},
  journal={Drug metabolism and pharmacokinetics},
  volume={27 1},
The cytochrome P450 (CYP) superfamily is one of the most important groups of enzymes involved in drug metabolism. It is responsible for the metabolism of a large number of drugs. Many CYP isoforms are expressed polymorphically, and catalytic alterations of allelic variant proteins can affect the metabolic activities of many drugs. The CYP2D6, CYP2C9, CYP2C19, and CYP2B6 genes are particularly polymorphic, whereas CYP1A1, CYP1A2, CYP2E1, and CYP3A4 are relatively well conserved without common… CONTINUE READING

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