In vitro assessment of reproductive toxicity of tobacco smoke and its constituents.
@article{Talbot2008InVA,
title={In vitro assessment of reproductive toxicity of tobacco smoke and its constituents.},
author={Prudence Talbot},
journal={Birth defects research. Part C, Embryo today : reviews},
year={2008},
volume={84 1},
pages={
61-72
}
}Epidemiological studies have repeatedly shown that reproductive processes in pregnant women are adversely affected by exposure to cigarette smoke. The potential reproductive targets of smoke during pregnancy include the ovaries, oviducts, uterus, placenta, umbilical cord, and embryo/fetus. In vitro methods for studying the effects of smoke and its individual components have been developed and applied to each of these reproductive targets. In vitro assays have been useful in determining the…
43 Citations
In vitro assessment of reproductive toxicity of cigarette smoke and deleterious consequences of maternal exposure to its constituents.
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BACKGROUND
Embryonic stem cells (ESC), which originate from the inner cell mass of blastocysts, are valuable models for testing the effects of toxicants on preimplantation development. In this study,…
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Assays show thatSS smoke from harm reduction cigarettes was at least as potent or in some cases more potent than smoke from a conventional brand and that SS smoke was more inhibitory than MS smoke in all assays.
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