In vitro assessment of reproductive toxicity of tobacco smoke and its constituents.

@article{Talbot2008InVA,
  title={In vitro assessment of reproductive toxicity of tobacco smoke and its constituents.},
  author={Prudence Talbot},
  journal={Birth defects research. Part C, Embryo today : reviews},
  year={2008},
  volume={84 1},
  pages={
          61-72
        }
}
  • P. Talbot
  • Published 1 March 2008
  • Biology
  • Birth defects research. Part C, Embryo today : reviews
Epidemiological studies have repeatedly shown that reproductive processes in pregnant women are adversely affected by exposure to cigarette smoke. The potential reproductive targets of smoke during pregnancy include the ovaries, oviducts, uterus, placenta, umbilical cord, and embryo/fetus. In vitro methods for studying the effects of smoke and its individual components have been developed and applied to each of these reproductive targets. In vitro assays have been useful in determining the… 
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TLDR
The present findings demonstrate the adverse effects of smoke constituents of mammalian reproduction and the differences in sensitivity to smoke components between male and female gametes.
Tobacco and pregnancy: overview of exposures and effects.
  • J. M. Rogers
  • Medicine
    Birth defects research. Part C, Embryo today : reviews
  • 2008
TLDR
Fertility, conception, survival of the conceptus, most phases and aspects of development studied to date, as well as postnatal survival and health are adversely impacted by maternal tobacco use or exposure.
Comparison of toxicity of smoke from traditional and harm-reduction cigarettes using mouse embryonic stem cells as a novel model for preimplantation development.
BACKGROUND Embryonic stem cells (ESC), which originate from the inner cell mass of blastocysts, are valuable models for testing the effects of toxicants on preimplantation development. In this study,
Using Embryonic Stem Cells as a Novel Model to Compare the Toxicological Effects of Harm Reduction and Conventional Cigarette Smoke on Early Embryo Development
TLDR
The use of mouse and human embryonic stem cells as a pre-implantation model and data demonstrated that non-cytotoxic doses of conventional and harm reduction cigarette SS smoke impaired hESC colony attachment and growth significantly, but MS smoke did not, clearly demonstrates the need to monitor harm reduction products carefully.
Comparison of the toxicity of smoke from conventional and harm reduction cigarettes using human embryonic stem cells.
TLDR
Assays show thatSS smoke from harm reduction cigarettes was at least as potent or in some cases more potent than smoke from a conventional brand and that SS smoke was more inhibitory than MS smoke in all assays.
Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments.
Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
TLDR
In this work, the utilization of an in vitro exposure system to expose human organotypic bronchial and nasal tissue models to mainstream CS is demonstrated and CS-induced alterations of xenobiotic metabolism that were similar to those observed in the bronchia and nasal epithelial cells obtained from smokers are demonstrated.
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