In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii.

@article{Fichera1995InVA,
  title={In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii.},
  author={Maria E. Fichera and Mahendra K. Bhopale and David S. Roos},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 7},
  pages={1530-7}
}
In order to characterize the delayed effect of clindamycin and macrolide antibiotics against Toxoplasma gondii tachyzoites (E. R. Pfefferkorn and S. E. Borotz, Antimicrob. Agents Chemother. 38:31-37, 1994), we have carefully examined the replication of parasites as a function of time after drug addition. Intracellular tachyzoites treated with up to 20 microM clindamycin (> 1,000 times the 50% inhibitory concentration) exhibit doubling times indistinguishable from those of controls… CONTINUE READING
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