In vitro antiviral activity of single domain antibody fragments against poliovirus.

@article{Thys2010InVA,
  title={In vitro antiviral activity of single domain antibody fragments against poliovirus.},
  author={Bert Thys and Lise Schotte and Serge Muyldermans and Ulrich Wernery and Gholamreza Hassanzadeh-Ghassabeh and Bart Rombaut},
  journal={Antiviral research},
  year={2010},
  volume={87 2},
  pages={257-64}
}
VHHs or Nanobodies are single-domain antigen-binding fragments derived from heavy chain antibodies found in camelids. It has already been shown that complex protein mixtures and even whole organisms elicit good immune responses in camelids; therefore we hypothesized that VHHs selected from a dromedary immunized with poliovirus type 1 might inhibit the in vitro replication of poliovirus through binding to essential biological sites on the viral capsid. In this study, we aimed to determine… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…