In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands.

@article{Santini2011InVA,
  title={In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands.},
  author={Carlo Santini and Maura Pellei and Grazia Papini and Barbara Morresi and Rossana Galassi and Simone Ricci and Francesco Tisato and Marina Porchia and Maria Pia Rigobello and Valentina Gandin and C. M. Asinari di San Marzano},
  journal={Journal of inorganic biochemistry},
  year={2011},
  volume={105 2},
  pages={232-40}
}
Hydrophilic, monocationic [M(L)(4)]PF(6) complexes (M = Cu or Ag; L: thp = tris(hydroxymethyl)phosphine, L: PTA = 1,3,5-triaza-7-phosphaadamantane, L: thpp = tris(hydroxypropyl)phosphine) were synthesized by ligand exchange reaction starting from [Cu(CH(3)CN)(4)]PF(6) or AgPF(6) precursors at room temperature in the presence of an excess of the relevant phosphine. The related [Au(L)(4)]PF(6) complexes (L = thp, PTA or thpp) were synthesized by metathesis reactions starting from [Au(L)(4)]Cl at… CONTINUE READING