In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids.

@article{Parajuli2009InVA,
  title={In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids.},
  author={Prahlad Parajuli and Nirmal Joshee and Agnes M. Rimando and Sandeep Mittal and Anand Kumar Yadav},
  journal={Planta medica},
  year={2009},
  volume={75 1},
  pages={
          41-8
        }
}
Scutellaria is a traditional herbal remedy with potential anti-cancer activity. The purpose of this study was to evaluate anticancer mechanisms of thirteen Scutellaria species and analyze their leaf, stem and root extracts for levels of common biologically active flavonoids: apigenin, baicalein, baicalin, chrysin, scutellarein, and wogonin. Malignant glioma, breast carcinoma and prostate cancer cells were used to determine tumor-specific effects of Scutellaria on cell proliferation, apoptosis… 
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The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells.
TLDR
Results demonstrate that as a herbal product, the S. baicalensis root extract is a potential inhibitor of tumori- and angiogenesis and may be valuable in the development of pharmaceutical medications for the treatment of oral squamous cell carcinoma.
Total flavonoid aglycones extract in Radix scutellariae inhibits lung carcinoma and lung metastasis by affecting cell cycle and DNA synthesis.
Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways.
Identification and Analysis of the Active Phytochemicals from the Anti-Cancer Botanical Extract Bezielle
TLDR
The results support the hypothesis that a major Scutellaria flavonoid, scutellarein, possesses many if not all of the biologically relevant properties of the total extract, which indicates that the activity of total Bezielle extract might depend on a combination of several different compounds present within it.
Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives.
Inhibitory and Cytotoxic Activities of Chrysin on Human Breast Adenocarcinoma Cells by Induction of Apoptosis
TLDR
This study shows that chrysin could also be considered as a promising chemotherapeutic agent and anticancer activity in treatment of the breast cancer cells in future.
Chrysin rich Scutellaria discolor Colebr. induces cervical cancer cell death via the induction of cell cycle arrest and caspase-dependent apoptosis.
Suppression of Taxanes Cytotoxicity by Citrus Flavonoid Hesperetin in PPC-1 Human Prostate Cancer Cells
TLDR
Flavonoid hesperetin remarkably suppressed the cytotoxic efficacy of taxanes in prostate cancer cells, and caution is required from prostate cancer patients who take he Speretin-containing oral supplements.
Scutellaria extract decreases the proportion of side population cells in a myeloma cell line by down-regulating the expression of ABCG2 protein.
TLDR
The results for the first time demonstrated a novel mechanism of action for Scutellaria extract and its main active flavonoids, namely targeting SP cells by modulating the expression of ABCG2 protein in RPMI-8226 in vitro.
Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects
TLDR
It is suggested that wogonin may be a useful chemotherapeutic adjuvant to potentiate the pharmacological action of etoposide and ameliorate its adverse effects.
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References

SHOWING 1-10 OF 32 REFERENCES
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Molecular Mechanism of Anti-Prostate Cancer Activity of Scutellaria Baicalensis Extract
TLDR
It is demonstrated that S. baicalensis may be a novel anticancer agent for the treatment of prostate cancer.
Characterization of Chemical Constituents in Scutellaria baicalensis with Antiandrogenic and Growth-Inhibitory Activities toward Prostate Carcinoma
TLDR
Most of the anticancer activities of S. baicalensis can be recapitulated with four purified constituents that function in part through inhibition of the androgen receptor signaling pathway, and clinical studies evaluating the efficacy of these agents in the context of chemoprevention or the treatment of prostate cancer are warranted.
Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells
TLDR
The results of this study support the efficacy of S. baicalensis as an anticancer agent for glioblastomas multiforme and a potential adjuvant treatment to current chemotherapeutic agents used in the treatment of both primary and recurrent GBMs.
Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents
TLDR
Bio‐based assays showed that non‐polar and low-polar solvent fractions of SB had dose‐dependent cytotoxicities on six cancer cell lines and the chloroform fraction had the strongest cytotoxicity on cancer cell Lines with a lower cytot toxic effect on a normal liver cell line.
Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines.
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TLDR
Differences in biological effects of Scutellaria baicalensis compared with baicalein suggest the synergistic effects among components in ScUTellaria Baicalensis, and selectively and effectively inhibits cancer cell growth in vitro and in vivo and can be an effective chemotherapeutic agent for HNSCC.
Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine.
Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells
Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells.
TLDR
HLJDT and Scutellaria radix have an antiproliferative effect on myeloma cells, and baicalein may be responsible for the suppressive effect of Scutella radix by blocking IkB-alpha degradation.
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