In vitro antitumor effect of hydroxyurea on hormone-refractory prostate cancer cells and its potentiation by phenylbutyrate.

@article{Figg1994InVA,
  title={In vitro antitumor effect of hydroxyurea on hormone-refractory prostate cancer cells and its potentiation by phenylbutyrate.},
  author={William D. Figg and R G Walls and Michael R. Cooper and Alain A Thibault and Oliver A Sartor and Nancy McCall and Charles E. Myers and Dvorit Samid},
  journal={Anti-cancer drugs},
  year={1994},
  volume={5 3},
  pages={336-42}
}
Previous clinical trials have suggested that hydroxyurea may possess some activity against prostate cancer. The in vitro antiproliferative activity of hydroxyurea was evaluated in three hormone-refractory prostate cancer cell lines, PC-3, DU-145 and PC-3M. Fifty-percent inhibition of growth in all three cell lines required prolonged (120 h) exposure to… CONTINUE READING