In vitro antitumor activity of 2'-deoxy-5-fluorouridine-monoclonal antibody conjugates.

@article{Goerlach1991InVA,
  title={In vitro antitumor activity of 2'-deoxy-5-fluorouridine-monoclonal antibody conjugates.},
  author={A Goerlach and Kenia G Krauer and Ian F.C. Mckenzie and Geoffrey A. Pietersz},
  journal={Bioconjugate chemistry},
  year={1991},
  volume={2 2},
  pages={96-101}
}
5-Fluorouracil (5-FU) is an anticancer drug used in patients for the treatment of gastric and breast cancer and used either alone or in combination with methotrexate is one of the few drugs with some effect on colon cancer. 2'-Deoxy-5-fluorouridine (5-FUdr) (1) is an analogue based on 5-FU and can be covalently linked to a murine anti-Ly-2.1 monoclonal antibody (mAb) with the active ester derivative of 2'-deoxy-5-fluoro-3'-O-(carboxypropanoyl)uridine (5-FUdr-succ) (4). Such immunoconjugates can… CONTINUE READING