In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica.

@article{Bawm2008InVA,
  title={In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica.},
  author={Saw Bawm and Hideyuki Matsuura and Ahmed Elkhateeb and Kensuke Nabeta and Subeki and Nariaki Nonaka and Yuzaburo Oku and Ken Katakura},
  journal={Veterinary parasitology},
  year={2008},
  volume={158 4},
  pages={
          288-94
        }
}
The medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae) is widely distributed throughout Asia where its bitter fruits have been used in traditional medicine for various ailments. Fifteen C-20 quassinoids were isolated from the fruits of B. javanica and examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Bruceine A, bruceantinol, bruceine C, brusatol, and bruceine B showed strong antitrypanosomal activities with IC(50) values in the range… 
Antitrypanosomal activities of acetylated bruceines A and C; a structure–activity relationship study
TLDR
Bruceines A, C, and bruceantinol were found to be the most potent compounds against T. evansi and the free hydroxyl groups at positions C-3, C-11, and C-12 are essential for antitrypanosomal activity.
In Vitro Antiprotozoal and Cytotoxic Activity of the Aqueous Extract, the 80% Methanol Extract and Its Fractions from the Seeds of Brucea sumatrana Roxb. (Simaroubaceae) Growing in Democratic Republic of Congo
The in vitro antiprotozoal and cytotoxic activity of the aqueous extract, the 80% methanol extract, and its different soluble fractions and subfractions from Brucea sumatrana seeds were assessed
In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
TLDR
Evidence that the isolated compounds might be potential sources of new anti-parasitic drugs for the control of Dactylogyrus intermedius is provided, following the first report on an in vivo anthelmintic investigation for B. javanica against D. intermedius.
Evaluation of Myanmar medicinal plant extracts for antitrypanosomal and cytotoxic activities.
TLDR
The methanol extract of dried rootbark of Vitis repens showed the highest antitrypanosomal activity and the highest selectivity index, while extracts of Brucea javanica, Vitex arborea, Eucalyptus globulus and Jatropha podagrica had also remarkable activity.
Antiprotozoal and cytotoxic activities, and the acute toxicity of extracts from of Brucea sumatrana Roxb. (Simaroubaceae) leaves collected in Mai-Ndombe, Democratic Republic of Congo
Results from the in vitro evaluation of the antiprotozoal activity of the aqueous extract, the 80% methanol extract and its fractions from the leaves of Brucea sumatrana against Trypanosoma brucei
Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of Brucea sumatrana (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo
Results from the in vitro evaluation of the antiparasitaire activity of the aqueous extract, the 80% methanol extract and its fractions from the leaves of Brucea sumatrana against Trypanosoma
Activity of selected phytochemicals against Plasmodium falciparum.
According to the WHO, in 2008, there were 247 million reported cases of malaria and nearly one million deaths from the disease. Parasite resistance against first-line drugs, including artemisinin and
Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae)
TLDR
The chemical investigation of the root barks leaves and stem barks of Brucea antidysenterica led to the isolation of a new pregnane glycoside, named Bruceadysentoside A or 3-O-β-L-arabinopyranosyl-pregn-5-en-20-one (1) together with seventeen known compounds.
Brusatol isolated from Brucea javanica (L.) Merr. induces apoptotic death of insect cell lines.
TLDR
Brusatol demonstrated cytotoxic effects to the tested insect cell lines, IOZCAS-Spex-II and Sf21, in a time- and dose-dependent manner, and indicated the existence of apoptotic death with the mitochondrial-dependent pathway induced by brusatol in S f21 and IOF21 cell lines.
Seven Quassinoids from Fructus Bruceae with Cytotoxic Effects on Pancreatic Adenocarcinoma Cell Lines
TLDR
Brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC50 values of 0.36 µm and 0.10 ²m on PANC‐1 and SW1990 cell lines, respectively, in the first report on the antipANCreatic adenocarcinoma activity of brusatol.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.
Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro. Of these extracts, the fruit of Brucea javanica was the
Anti-babesial Quassinoids from the Fruits of Brucea Javanica
TLDR
This is the first report of the anti-babesial activity of these isolated quassinoids, found to be attributed to its quassinoid constituents in Brucea javanica, grown in China.
Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids
TLDR
A microdilution technique for the assessment of in vitro activity against Entamoeba histolytica was devised and validated with metronidazole and will be useful in the search for novel antiamoebic drugs.
Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis.
TLDR
The present results suggest that bruceine A or other related compounds are potential candidates for the treatment of canine babesiosis and decreases in the packed cell volume and the erythrocyte and platelet counts were observed.
In vitro antimalarial activity of Brucea javanica against multi-drug resistant Plasmodium falciparum.
The medicinal plant, BRUCEA JAVANICA (L.) Merr. (Simaroubaceae) was examined for antimalarial properties. Among different crude solvent extracts of the fruit, the chloroform extract was shown to have
In vitro cytotoxicity of a series of quassinoids from Brucea javanica fruits against KB cells.
TLDR
It is suggested that the quassinoid mode of antimalarial action is not a simple cytotoxic effect and lends support to further investigation of the structure activity relationships within this group of compounds.
Plants as sources of antimalarial drugs, Part 4: Activity of Brucea javanica fruits against chloroquine-resistant Plasmodium falciparum in vitro and against Plasmodium berghei in vivo.
TLDR
Four quassinoids were found to possess activity in vivo against Plasmodium berghei infections in mice after oral dosing, and all five quassinoid tested in vivo showed some toxicity.
In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum.
TLDR
It is concluded that in the malaria parasite, as in eukaryote models, quassinoids are rapid and potent inhibitors of protein synthesis, and that this is most likely due to effects upon the ribosome, rather than upon nucleic acid metabolism.
Quassinoids Exhibit Greater Selectivity Against Plasmodium Falciparum Than Against Entamoeba Histolytica, Giardia Intestinalis Or Toxoplasma Gondii In Vitro
TLDR
The results suggest that quassinoids have a selective action on P. falciparum, and further studies to elucidate the basis for this are in progress.
Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids
TLDR
Fourteen quassinoids, obtained from simaroubaceous plants, were tested for in vitro antimalarial activity and the results were compared with the antiamoebic, antileukemic, and cytotoxic activities of these compounds reported in the literature.
...
1
2
3
4
...