In vitro antiplasmodial and cytotoxicity activities of 14 medicinal plants from Kenya

@article{Irungu2007InVA,
  title={In vitro antiplasmodial and cytotoxicity activities of 14 medicinal plants from Kenya},
  author={B. Irungu and G. Rukunga and G. Mungai and C. Muthaura},
  journal={South African Journal of Botany},
  year={2007},
  volume={73},
  pages={204-207}
}
Abstract Organic and aqueous extracts obtained from 14 Kenyan medicinal plants were screened for their antimalarial properties on two strains of Plasmodium falciparum (K1 chloroquine resistant and NF54 chloroquine sensitive). Dichloromethane extracts had the highest activities with IC 50 ranging from 1.4 to 35.2 μg/ml. These extracts together with methanol extract of Turraea robusta were tested for their cytotoxicity properties in vitro on mammalian L6 cell line. The cytotoxicities ranged from… Expand

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References

SHOWING 1-10 OF 18 REFERENCES
In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects.
TLDR
The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ. Expand
In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria.
TLDR
Five plants commonly used in West tropical Africa by traditional healers for the treatment of malaria were collected and ethanolic extracts were obtained by decoction, associating good antiplasmodial activity and weak cytotoxicity. Expand
In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa.
TLDR
The results of the present study support a rational rather than random approach to the selection of antiplasmodial screening candidates, and identify a number of promising taxa for further investigation as plant-based antimalarial agents. Expand
Antimalarial activity of medicinal plants used in traditional medicine in S. Tomé and Príncipe islands.
TLDR
The results indicate that the traditional healers in STP use several medicinal plants against fever and/or 'malaria' which reveal strong antiparasitic activity in vitro: four of the plant extracts have evident antiplasmodial activity against chloroquine resistant Plasmodium falciparum. Expand
Evaluation of plants used for antimalarial treatment by the Maasai of Kenya.
TLDR
The results of this preliminary investigation support the traditional knowledge of Maasai herbalists and justify ethnomedical inquiry as a promising method, specifically, in antimalarial therapy, to yield leads for drug discovery. Expand
Antitrypanosomal and antiplasmodial activity of medicinal plants from Côte d'Ivoire.
TLDR
The antitrypanosomal activity of 101 crude ethanol extracts derived from 88 medicinal plants from Côte d'Ivoire was determined in vitro using Trypanosoma brucei rhodesiense, finding that Enantia polycarpa stem bark and Trichilia emetica were the most promising ones. Expand
Anti-plasmodial activity and toxicity of extracts of plants used in traditional malaria therapy in Meru and Kilifi Districts of Kenya.
TLDR
Traditional herbs used to treat malaria in Meru and Kilifi Districts, Kenya, are supported and their potential as sources of drugs for anti-malarial therapy are demonstrated. Expand
Antimalarial activity of Ajuga remota Benth (Labiatae) and Caesalpinia volkensii Harms (Caesalpiniaceae): in vitro confirmation of ethnopharmacological use.
TLDR
Field trips to herbalists' practices in an area about 200 miles around Nairobi (Kenya) enabled us to make a list of medicinal plant species preferentially used to treat malaria, which included Ajuga remota and Caesalpinia volkensii as being the most frequently used species. Expand
Antiparasitic properties of medicinal plants and other naturally occurring products.
TLDR
This chapter has drawn together a comprehensive list of medicinal plants and other natural products that have been shown to have activity against human and, to a lesser extent, animal parasites. Expand
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.
TLDR
A rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against cultured intraerythrocytic asexual forms of the human malaria parasite Plasmodium falciparum, and results demonstrated that the method is sensitive and precise. Expand
...
1
2
...