In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects.

Abstract

Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC(50) < 100 microg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC(50) values ranging less than 30 microg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.

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@article{Muregi2003InVA, title={In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects.}, author={Francis W Muregi and Sumesh C Chhabra and Eliud Nyaga Mwaniki Njagi and Caroline C Lang'at-Thoruwa and Wilson M Njue and Alloys S S Orago and Samira A Omar and Isaiah Omolo Ndiege}, journal={Journal of ethnopharmacology}, year={2003}, volume={84 2-3}, pages={235-9} }