In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.

@article{Wright2000InVA,
  title={In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.},
  author={Colin W. Wright and Sarah Marshall and Paul F. Russell and Melody M Anderson and J. David Phillipson and Geoffrey C. Kirby and David Charles Warhurst and Paul L. Schiff},
  journal={Journal of natural products},
  year={2000},
  volume={63 12},
  pages={1638-40}
}
Twenty-one alkaloids have been assessed for activities against Plasmodium falciparum (multidrug- resistant strain K1) in vitro; 18 of these are reported for the first time. Two protoberberine alkaloids, dehydrodiscretine and berberine, were found to have antiplasmodial IC(50) values less than 1 M, while seven alkaloids-allocrytopine, columbamine, dehydroocoteine, jatrorrhizine, norcorydine, thalifendine, and ushinsunine-had values between 1 and 10 M. These results are discussed in the context… CONTINUE READING

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