In vitro antimicrobial activity of cefpirome, a new cephalosporin with a broad antimicrobial spectrum.

  title={In vitro antimicrobial activity of cefpirome, a new cephalosporin with a broad antimicrobial spectrum.},
  author={S. Arai and S. Kobayashi and S. Hayashi and K. Fujimoto},
  journal={The Japanese journal of antibiotics},
  volume={40 5},
The in vitro activity of cefpirome (HR 810), a new cephalosporin antibiotic having a 2,3-cyclopentenopyridine group in the 3-position side chain, was compared with in vitro activities of 5 other cephalosporins. HR 810 showed a broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria when tested using 71 standard strains and 876 clinical isolates. HR 810 inhibited 70% of the clinically isolated Staphylococcus aureus and Staphylococcus epidermidis strains when… Expand
The antimicrobial activity in vitro of cefpirome and 6 other beta-lactam antibacterial agents against clinical isolates.
CPR was a new broad spectrum cephalosporin as compared with used cep Halosporins, and more effective than CEZ, CTM and FMOX. Expand
Therapeutic effects of cefpirome, a new cephalosporin, on various models of infections in mice and rats.
HR 810 was superior to cefuzonam (CZON) and cefmetazole against MRSA and MSSA and was much more active than any other antibiotics tested against E. cloacae and A. calcoaceticus and Enterococcus faecalis. Expand
Therapeutic effects of cefpirome (HR 810) on experimental mixed infections with enterococcus faecalis and escherichia coli in mice
Cefpirome was more effective in protecting mice with systemic mixed infection than the other antibiotics and the percentages of the animals havingE. Expand
Distribution of cefpirome (HR 810) to exudate in the croton oil-induced rat granuloma pouch and its therapeutic effects on experimental infections in the pouch
Cefpirome had the strongest activity against Staphylococcus aureus Smith infection among the five antibiotics, showing bactericidal effects and long-lasting bacterial growth-inhibitory effects. Expand
小児科領域における Cefpirome の薬物動態と臨床的検討
The results suggest that CPR may be an effective and safe drug to use on children clinically and that bacteria in children were followed after administration of CPR to identify strains that showed transient eosinophilia and the other showed a transient increase of transaminase. Expand
In‐vitro and in‐vivo studies of cefpirom using bile salts as absorption enhancers
Cefpirom is a new semi‐synthetic amino‐2‐thiazolyl‐methoxyimino cephalosporin that has been substituted in position 3 with a cyclopenteno‐pyridinium group in order to create a zwitterionic compound that exhibits highly hydrophilic properties, as shown from its extremely low partition coefficient. Expand
小児科領域における Cefpirome の基礎的, 臨床的検討
An efficacy rate of 100% was obtained and eruption was observed in 1 of the 18 patients, but when administration was discontinued, the symptom gradually receded, and it disappeared by the 4th day. Expand


Antibacterial activity of ceftizoxime, a beta-lactamase-stable cephalosporin
  • K. Fu, H. Neu
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1980
Cftizoxime was the most active agent tested against Escherichia coli and Klebsiella, inhibiting 80% at 0.025 microgram/ml, and was more active than cefotaxime against Enterobacter cloacae and E. aerogenes. Expand
Ceftizoxime (FK 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities
FK 749 has, in general, nearly the same in vitro and in vivo antibacterial activities as cefotaxime, and the former had more potent bactericidal activity in the presence of the blood than the latter and showed more excellent therapeutic effect against infections caused by large inoculum sizes. Expand
In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains
The drug most active against beta-lactamase-positive N. gonorrhoeae and H. influenzae was cefotaxime, followed closely by cefoperazone, moxalactam, piperacillin, and mezlocillin. Expand
In vitro activity of HR 810, a new cephalosporin
On a weight basis, the activity of HR 810 against gram-negative bacilli was equivalent or superior to that of the other beta-lactam agents except imipenem. Expand
Pharmacokinetic properties of the new cephalosporin antibiotic HR 810 in animals
While large amounts of the antibiotic were recovered in the animals' urine, the recovery rate in bile was very low and open the way for the evaluation of HR 810 in humans. Expand