In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway.

@article{Pantovic2017InVA,
  title={In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway.},
  author={Aleksandar C Pantovic and Mihajlo Bosnjak and Katarina M Arsikin and Milica Kosic and Milos Mandic and Biljana Z Ristic and Jelena Tosic and Danica Gruji{\vc}i{\'c} and Aleksandra J. Isakovic and Nikola Micic and Vladimir Trajkovic and Ljubica M Harhaji-Trajkovic},
  journal={The international journal of biochemistry & cell biology},
  year={2017},
  volume={83},
  pages={84-96}
}
We investigated the role of the intracellular energy-sensing AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway in the in vitro antiglioma effect of the cyclooxygenase (COX) inhibitor indomethacin. Indomethacin was more potent than COX inhibitors diclofenac, naproxen, and ketoprofen in reducing the viability of U251 human… CONTINUE READING