Corpus ID: 35316540

In vitro antigiardial activity of IRE-6A and IRE-7B, two ethyl-phenylcarbamate derivatives.

@article{JimnezCardoso2003InVA,
  title={In vitro antigiardial activity of IRE-6A and IRE-7B, two ethyl-phenylcarbamate derivatives.},
  author={Enedina Jim{\'e}nez-Cardoso and Andr{\'e}s Flores-Luna and Enrique {\'A}ngeles and Pablo A. Mart{\'i}nez and Rafael L{\'o}pez-Casta{\~n}ares and Gilberto Casta{\~n}eda-Hern{\'a}ndez and Jos{\'e} P{\'e}rez-Urizar},
  journal={Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion},
  year={2003},
  volume={55 4},
  pages={
          444-7
        }
}
Resistance is a practical problem associated to the use of benzimidazoles in the antigiardial therapy. Since benzimidazole-resistant strains of fungi have shown increased sensitivity to phenylcarbamates, in this study we synthesized and in vitro tested novel substituted phenylcarbamates against the protozoa Giardia intestinalis. IRE-6A and IRE-7B, two 4-R-ethyl-phenylcarbamates demonstrated an important antigiardial activity although that was modest when compared to albendazole in axenic… Expand
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