In vitro antigenotoxicity of Ulva rigida C. Agardh (Chlorophyceae) extract against induction of chromosome aberration, sister chromatid exchange and micronuclei by mutagenic agent MMC.

@article{elikler2008InVA,
  title={In vitro antigenotoxicity of Ulva rigida C. Agardh (Chlorophyceae) extract against induction of chromosome aberration, sister chromatid exchange and micronuclei by mutagenic agent MMC.},
  author={S. Çelikler and G. Yıldız and O. Vatan and R. Bilaloğlu},
  journal={Biomedical and environmental sciences : BES},
  year={2008},
  volume={21 6},
  pages={
          492-8
        }
}
OBJECTIVE To determine the in vitro possible clastogenic and cytotoxic activities of Ulva rigida crude extracts (URE), and identify their antigenotoxic and protective effects on chemotherapeutic agent mitomycine-C (MMC). METHODS Anti-clastogenic and anti-genotoxic activities of Ulva rigida crude extracts (URE) were studied using chromosome aberration (CA), sister chromatid exchange (SCE), and micronuclei (MN) tests in human lymphocytes cultured in vitro. RESULTS The chromosome aberration… Expand
In vitro antigenotoxic and anti-oxidative capacity of Hypnea musciformis (Wulfen) Lamouroux extract in human lymphocytes
Several hazardous substances, can damage our DNA in various ways. Defining these substances and the protective ones is very important. Therefore, researches have increased on various compounds basedExpand
Anticlastogenic Effect of Ulva Fasciata, Against Cyclophosphamide and Mitomycin C Induced Chromosomal Damage in Swiss Albino Mice
TLDR
The results show that Ulva extract gave significant protection against the CP and MMC induced damages by reducing micronucleus and chromosomal aberrations. Expand
Evaluation of anti-oxidative, genotoxic and antigenotoxic potency of Codium tomentosum Stackhouse ethanolic extract in human lymphocytes in vitro.
TLDR
This work evaluated the antigenotoxic/antimutagenic activity of the crude ethanolic extracts of Codium tomentosum Stackhouse (Chlorophyceae) (CTE), collected from The Coast of South East Marmara Sea, in human lymphocytes culture in vitro against genot toxic/mutagenic agents MMC, EMS and H(2)O(2). Expand
Protective and antigenotoxic effect of Ulva rigida C. Agardh in experimental hypothyroid.
TLDR
This is the first in vivo study that shows the strong antigenotoxic and protective effect of URE against the genotoxicity produced by hypothyroidism. Expand
Assessment of antigenotoxic effect brown seaweed Stoechospermum marginatu
TLDR
It is indicated that methanolic extract of Stoechospermum marginatum possessed an antigenotoxic activity and can confer protective effects to living cell genome against the deleterious effects of various chemical mutagens and clastogens following exposure. Expand
Protective effect of Kappaphycus alvarezii (Rhodophyta) extract against DNA damage induced by mercury chloride in marine fish
TLDR
Results suggested that under present experimental conditions, K. alvarezii extract exhibit potent anti-genotoxicity effects in this fish model; and thus these extracts may be recommended as a supplement in fish meal and may benefit humans ingesting Hg-contaminated fish. Expand
In vitro evaluation of the protective effects of 4-thujanol against mitomycin-C and cyclophosphamide-induced genotoxic damage in human peripheral lymphocytes
TLDR
It is suggested that 4-thujanol may improve the chemopreventive effects and may also reduce the harmful side effects of CP, which is widely used in chemotherapy against cancer, without reducing its antiproliferative activities. Expand
Role of recombinant human erythropoietin in mitomycin C-induced genotoxicity: analysis of DNA fragmentation, chromosome aberrations and micronuclei in rat bone-marrow cells.
TLDR
The results show that MMC induced a noticeable genotoxic effect in rat bone-marrow cells, and rhEPO reduced the effects of MMC significantly in every type of experiment conducted, such as the frequency of micronuclei, the percentage of chromosome aberrations and the level of DNA damage measured with the comet assay. Expand
Evaluation of chromosome aberrations induced by digoxin in Chinese hamster ovary cells
TLDR
All concentrations that cause chromosomal aberrations are in the cytotoxic range of the drug. Expand
Evaluation of antigenotoxic effects of carotenoids from green algae Chlorococcum humicola using human lymphocytes.
TLDR
The findings of the present study demonstrate that, the green algae C. humicola is a rich source of bioactive compounds especially carotenoids which effectively fight against environmental genotoxic agents, the carOTenoids itself is not a genot toxic substance and should be further considered for its beneficial effects. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 49 REFERENCES
Protective effect of DCTN (trans-dehydrocrotonin) against induction of micronuclei and apoptosis by different mutagenic agents in vitro.
TLDR
The micronucleus test showed a protective effect for DCTN which varied among the different treatment protocols and with regard to the different DNA damage inducing agents, support the indication of this active principle at these concentrations for therapeutic use. Expand
The in vitro micronucleus technique.
  • M. Fenech
  • Biology, Medicine
  • Mutation research
  • 2000
TLDR
In its current basic form the CBMN assay can provide the following measures of genotoxicity and cytotoxicity: chromosome breakage, chromosome loss, chromosome rearrangement, cell division inhibition, necrosis and apoptosis. Expand
beta-Carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture.
TLDR
Findings suggest that beta-carotene can modify the DNA damaging effect of the carcinogens and thereby may also prevent the initiation of the cancerogenic process. Expand
Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts.
TLDR
The aqueous extract of spirulina was chosen as the source of antioxidant to investigate the inhibitory effect on the proliferation of HSC and triggered a cell cycle arrest of H SC at the G2/M phase. Expand
Preliminary study of the in vitro antiproliferative effect of a hydroethanolic extract from the subtropical seaweed Turbinaria ornata (Turner) J. Agardh on a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)
TLDR
Observations suggest a triggering of the terminal differentiation of cancerous cells by this fucan-like polysaccharide. Expand
Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation.
TLDR
It is suggested that fucoxanthin, lutein, and THC may have potential as chemopreventive agents against colon carcinogenesis. Expand
HUman MicroNucleus project: international database comparison for results with the cytokinesis‐block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei
TLDR
The best model, which included exposure to genotoxic factors, host factors, methods, and scoring criteria, explained 75% of the total variance, with the largest contribution attributable to laboratory methods. Expand
Potent antibacterial activity of halogenated metabolites from Malaysian red algae, Laurencia majuscula (Rhodomelaceae, Ceramiales).
TLDR
This investigation delves upon extraction, isolation, structural elucidation and antibacterial activity of inherently available secondary metabolites of Laurencia majuscula Harvey collected from two locations in waters of Sabah, Malaysia. Expand
Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.
TLDR
From studies on their mechanism of action, it is concluded that polysulfates exert their anti-HIV activity by shielding off the positively charged sites in the V3 loop of the viral envelope glycoprotein (gp120). Expand
Antimutagenicity profiles for some model compounds.
TLDR
Activity profiles are useful for the assessment of the available antimutagenesis data by providing rapid visualization of considerable dose information and experimental results. Expand
...
1
2
3
4
5
...