In vitro anticancer property of a novel thalidomide analogue through inhibition of NF-κB activation in HL-60 cells

@inproceedings{Li2009InVA,
  title={In vitro anticancer property of a novel thalidomide analogue through inhibition of NF-$\kappa$B activation in HL-60 cells},
  author={Min Li and Wan Sun and Ya-ping Yang and Bo Xu and Wen-yuan Yi and Yan-xia Ma and Zhong-jun Li and Jing-rong Cui},
  booktitle={Acta Pharmacologica Sinica},
  year={2009}
}
  • Min Li, Wan Sun, +5 authors J. Cui
  • Published in Acta Pharmacologica Sinica 2009
  • Chemistry, Medicine
AbstractAim:To investigate the anticancer property and possible mechanism of action of a novel sugar-substituted thalidomide derivative (STA-35) on HL-60 cells in vitro.Methods:TNF-α-induced NF-κB activation was determined using a reporter gene assay. The MTT assay was used to measure cytotoxicity of the compound. The appearance of apoptotic Sub-G1 cells was detected by flow cytometry analysis. PARP cleavage and protein expression of NF-κB p65 and its inhibitor IκB were viewed by Western… 
LNO3 AND L3 Are Associated With Antiproliferative And Pro-Apoptotic Action In Hepatoma Cells
TLDR
It is suggested that L3 and LNO3 possess antiproliferative and pro-apoptotic effects in HTC cells, and they might be useful coadjuvants in tumor treatment studies.
SYNTHESIS AND ANTI-PROLIFERATIVE ACTIVITY OF SOME ISOINDOLINE-1, 3-DIONE DERIVATIVES AGAINST EHRLICH'S ASCITES CARCINOMA BEARING MICE MODEL
Five (1a-5e) isoindoline-1, 3-dione derivatives wer e synthesized and characterized by IR, 1 H NMR, and Mass spectroscopy. They were evaluated for in vivo anticancer activity against the Ehrlich
The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups.
TLDR
The anticancer activities of isoindole-1,3(2H)-dione compounds (8 - 23) vary depending on the groups they contain and these groups affect each other's activities, so compounds 13 and 16, containing both silyl ether (-OTBDMS) and -Br groups, showed higher anticancer activity than cisplatin against both Caco-2 and MCF-7 cells.
Novel thalidomide analogues with potent NFκB and TNF expression inhibition
A series of N-phenyl thalidomide analogues have been prepared efficiently through a Buchwald–Hartwig cross coupling reaction as the key step. Several of these compounds have extraordinary TNF
Breathing New Life into Old Drugs: Indication Discovery by Systems Directed Therapy
TLDR
Targeting the tumor stroma is judged to be a promising approach in tumor palliation because it is thought to be less susceptible to the development of drug resistance and to cause less ­toxicity.
Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments
TLDR
The role of neuro inflammation in neurodegenerative diseases is evaluated, focusing specifically on the role of TNF-α in neuroinflammation, as well as appraise current research on the potential of IMiDs as treatments for neurological disorders.
Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NFκB induced TNF-α.
TLDR
Thalidomide may inhibit TNF-α expression via down-regulation of the NFκB signaling pathway to alleviate acute pancreatitis-associated lung injury in rats.
Overcoming cancer therapeutic bottleneck by drug repurposing
TLDR
This review presents various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono- or drug combination therapy.
Synthesis, characterization and biological activity evaluation of new 3- methyl and 4- fluoro isoindoline-1, 3-dione/phthalimide analogues
Abstract The convenient route for the synthesis of a series of new Isoindoline-1, 3-dione/phthalimide analogues by condensation of substituted phthalic anhydride with an appropriate Ar-amine is
Redox control of teratogenesis.
TLDR
Examples of teratogens that induce ROS and oxidative injury are reviewed, oxidative stress-related teratogenic mechanisms are described, and rationale for developmental periods of sensitivity and species susceptibility is provided.
...
1
2
...

References

SHOWING 1-10 OF 47 REFERENCES
Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis.
TLDR
It is demonstrated that thalidomide might inhibit growth of tumors through COX-2 degradation independent of antiangiogenesis.
Inhibition of NF-κB Activity by Thalidomide through Suppression of IκB Kinase Activity*
The sedative and anti-nausea drug thalidomide, which causes birth defects in humans, has been shown to have both anti-inflammatory and anti-oncogenic properties. The anti-inflammatory effect of
The Thalidomide Analogue, CC-4047, Induces Apoptosis Signaling and Growth Arrest in Childhood Acute Lymphoblastic Leukemia Cells In vitro and In vivo
TLDR
The thalidomide analogue, CC-4047, displays profound cytostatic effects on stroma-supported human ALL cells both in vitro and in vivo.
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity.
TLDR
It is shown here that thalidomide can block NF-kappaB activation through a mechanism that involves the inhibition of activity of the IkappaB kinase.
Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells
TLDR
It is demonstrated that a substantial proportion of CLL are dependent on NF-κB for enhanced survival and suggest that inhibition of NF-σB may have therapeutic potential.
Can NF-kappaB be a target for novel and efficient anti-cancer agents?
TLDR
The most significant clinical data have been obtained with bortezomib, a proteasome inhibitor, for the treatment of multiple myeloma, and a review discusses the preclinical and clinical data obtained with these various drugs and their putative future developments.
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications.
TLDR
The mechanism of action of IMiDs against MM cells in vitro is delineated and form the basis for clinical trials of these agents, alone and coupled with conventional and other novel therapies, to improve outcome in MM.
Tumor necrosis factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study.
TLDR
A structure-activity relationship study of these phthalimide analogues revealed that their inhibitory effects on TPA- and OA-induced TNF-alpha production by THP-1 cells are well correlated to each other, i.e. they may involve the same target molecule(s).
Increased and correlated nuclear factor-kappa B and Ku autoantigen activities are associated with development of multidrug resistance
TLDR
The results proposed that the NF-κB and Ku activation could be one of multi-factorial MDR mechanism, and PKA inhibitor could enhance the effectiveness of anticancer drugs against MDR cells with high activities of NF-γB andKu.
Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues.
TLDR
The results support the further development and evaluation of novel thalidomide analogues as antiangiogenic agents and demonstrate antiproliferative action in human umbilical vein endothelial cells.
...
1
2
3
4
5
...