In vitro anticancer property of a novel thalidomide analogue through inhibition of NF-κB activation in HL-60 cells

  title={In vitro anticancer property of a novel thalidomide analogue through inhibition of NF-$\kappa$B activation in HL-60 cells},
  author={Min Li and Wan Sun and Ya-ping Yang and Bo Xu and Wen-yuan Yi and Yan-xia Ma and Zhong-jun Li and Jing-rong Cui},
  booktitle={Acta Pharmacologica Sinica},
  • Min Li, Wan Sun, +5 authors J. Cui
  • Published in Acta Pharmacologica Sinica 2009
  • Chemistry, Medicine
AbstractAim:To investigate the anticancer property and possible mechanism of action of a novel sugar-substituted thalidomide derivative (STA-35) on HL-60 cells in vitro.Methods:TNF-α-induced NF-κB activation was determined using a reporter gene assay. The MTT assay was used to measure cytotoxicity of the compound. The appearance of apoptotic Sub-G1 cells was detected by flow cytometry analysis. PARP cleavage and protein expression of NF-κB p65 and its inhibitor IκB were viewed by Western… 
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