In vitro antibacterial properties of EL-870, a new semi-synthetic macrolide antibiotic.

  title={In vitro antibacterial properties of EL-870, a new semi-synthetic macrolide antibiotic.},
  author={Earl Eugene Ose},
  journal={The Journal of antibiotics},
  volume={40 2},
  • E. E. Ose
  • Published 25 February 1987
  • Biology, Medicine
  • The Journal of antibiotics
A new macrolide antibiotic, EL-870, 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin, has been prepared by chemical modification of desmycosin. In vitro, against selected animal bacterial pathogens, it inhibited growth of Pasteurella multocida, Pasteurella haemolytica, Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Streptococcus suis, Actinomyces pyogenes and certain other bacteria at levels of 6.25 micrograms/ml or less. In general, the MICs for Gram-negative enteric bacteria… Expand
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Am. J. Vet. Res
  • Am. J. Vet. Res
  • 1986
In vitro antibacterial properties of EL-870
  • Program and Abstracts of the 25th Intersci. Conf. on Antimicrob. Agents Chemother.,
  • 1985
In vitro antibacterial properties of EL-870. Program and Abstracts of the 25th Intersci Ose: Synthesis and structure-activity studies of 20-deoxo-20-substituted amino-macrolide antibiotics
  • Conf. on Antimicrob. Agents Chemother
  • 1985
Synthesis and structure-activity studies of 20-deoxo-20-substituted amino-macrolide antibiotics
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  • 1985
Tylosin distribution in normal and pneumonic swine
  • Proc. Am. Assoc. Swine Pract. 1984:
  • 1984