In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin

@article{Basker1984InVA,
  title={In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin},
  author={Michael J. Basker and R. A. Edmondson and Sarah J. Knott and Roger J. Ponsford and Brian Slocombe and Scott White},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1984},
  volume={26},
  pages={734 - 740}
}
BRL 36650 is a new type of penicillin in which a formamido group has been introduced into the 6 alpha-position of the nucleus. The compound is highly active against aerobic gram-negative bacteria and is stable to a wide range of beta-lactamases produced by these organisms. Against members of the family Enterobacteriaceae, BRL 36650 was considerably more active than piperacillin, particularly against beta-lactamase-producing strains, and showed a similar level of activity to moxalactam… 
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Ten healthy volunteers received 1 g of BRL-36650, a new formamido-penicillin derivative, given by intravenous infusion over 15 min to study the study of serum bactericidal activity (SBA), and Killing curves confirmed the high bactericidal activities obtained against the majority of strains.
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