In vitro antibacterial activity of faeriefungin, a new broad-spectrum polyene macrolide antibiotic.

  title={In vitro antibacterial activity of faeriefungin, a new broad-spectrum polyene macrolide antibiotic.},
  author={Martha H. Mulks and Muraleedharan G Nair and Alan R. Putnam},
  journal={Antimicrobial agents and chemotherapy},
  volume={34 9},
The in vitro activity of faeriefungin, a new pentaene macrolide lactone antibiotic produced by Streptomyces griseus var. autotrophicus, against 263 clinical bacterial isolates was examined. In contrast to the related fungicidal antibiotics nystatin and amphotericin B, which show no activity against bacteria, faeriefungin showed bactericidal activity against all species of gram-positive bacteria examined. MICs for these species ranged from 8 to 64 micrograms/ml, and the MIC for 90% of the… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations


Publications referenced by this paper.
Showing 1-10 of 12 references

Susceptibility tests: special tests, p

  • F. D. Schoenknecht, L. D. Sabath, C. Thornsberry
  • Manual of clinical microbiology,
  • 1985

Antifungal antibiotics: mechanism of action, resistance, susceptibility testing, and assays of activity in biological fluids, p. 170-192

  • H. Chmel, D. B. Louria
  • 1980

Laboratory evaluation of new antibiotics in vitro and in experimental animal infections

  • R. Cleeland, E. Grunberg
  • 1980

Macrolide antibiotic studies. XVII. Cyclic hemiketal structures in nystatin, amphotericin B, primaricin, and lucensomycin

  • C. N. Chong, R. W. Rickards
  • 1972

Structure and absolute configuration of the polyene macrolide antibiotic amphotericin B

  • W. Mechlinski, C. P. Schaffner, P. Ganis, G. Avitabile
  • 1970

Similar Papers

Loading similar papers…