In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin

@article{Katsu1982InVA,
  title={In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin},
  author={Kanemasa Katsu and Kyosuke Kitoh and Matsuhisa Inoue and Susumu Mitsuhashi},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1982},
  volume={22},
  pages={181 - 185}
}
E-0702 is an antipseudomonal cephalosporin derivative which has a broad spectrum of antibacterial activity against clinical isolates of gram-positive and gram-negative bacteria. Its in vitro antibacterial activities were less than those of cefoperazone and cefotaxime against Staphylococcus aureus and Staphylococcus epidermidis, but were significantly high against gram-negative bacteria including the Pseudomonas group. It was most characteristic that E-0702 showed high antibacterial activity… 
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41 Citations
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Methods Citations
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41 Citations

In vitro antibacterial activity of KP-736, a new cephem antibiotic
KP-736, a new cephen antibiotic with a broad antibacterial spectrum and potent antipseudomonal activity, was evaluated for in vitro antibacterial activity in comparison with ceftazidime, cefotaxime,…
Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship.
Comparative Evaluation of GR 69153, a Catechol-Substituted Cephalosporin
SummaryThe in vitro activity of GR 69153, a new catechol-containing cephalosporin, was compared with other commonly used antibacterial agents against 651 isolates of Enterobacteriaceae, 204 isolates…
In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity
TLDR
E1040 is a new parenteral cephalosporin with a broad antibacterial spectrum and potent antipseudomonal activity and was at least as resistant as ceftazidime and cefmenoxime to hydrolysis by various beta-lactamases and showed high affinities for penicillin-binding protein 3 of both Escherichia coli and P. aeruginosa.
In vitro evaluation of U63196-E (AC-1370): Antimicrobial activity, β-lactamase stability, and β-lactamase inhibition
Antimicrobial activity of E-1040, a novel thiadiazolyl cephalosporin compared with other parenteral cephems.
In vitro and in vivo evaluation of Ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity
TLDR
The results indicate that Ro 09-1428 is a broad-spectrum cephalosporin with advantages over ceftazidime in its activity against P. aeruginosa, staphylococci, and ceftrazidime-resistant strains of C. freundii and E. cloacae.
E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system
TLDR
It is suggested that E-0702 is incorporated into bacterial cells as a chelator of iron via the tonB-dependent iron transport system, after which its strong and rapid bactericidal action is manifested.
Novel cephalosporins having a benzothiopyran group. 2. Synthesis and biological activity of catecholic benzothiopyran group at the C-3 side chain.
TLDR
These benzothiopyran cephalosporins exhibited broad and good antibacterial activity against both Gram-positive bacteria including Enterococcus faecalis and Gram-negative bacteria including Pseudomonasaeruginosa.
Antibacterial activity of BMS-180680, a new catechol-containing monobactam
TLDR
BMS-180680 was the only antibiotic evaluated that was active against >90% of the Pseudomonas aeruginosa, Burkholderia cepacia, and Stenotrophomonas maltophilia strains tested.
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